What is the Difference Between Hemoglobin and Hematocrit, Normal Hematocrit

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The main difference between hemoglobin and hematocrit is that hemoglobin is an iron-containing protein responsible for carrying oxygen to red blood cells, whereas hematocrit is the amount of red blood cells compared to total blood volume.

The main difference between hemoglobin and hematocrit is that hemoglobin is an iron-containing protein responsible for carrying oxygen to red blood cells, whereas hematocrit is the number of red blood cells compared to the total volume of blood. In addition, hemoglobin levels for men are 14 to 18 g / dL; 12 to 16 g / dL for women while normal hematocrit should be 40 to 54% for men; For women, it should be 36 to 48%.

Hemoglobin and hematocrit are two important measurements of the oxygen-carrying capacity of the blood. Hematocrit (%) is equal to three times the value of hemoglobin (g / dL).


Key areas covered

1. What is Hemoglobin 
- Definition, Measurement, Reference Value 
2. What is Hematocrit 
- Definition, Measurement, Reference Value 
3. What are the similarities between Hemoglobin and Hematocrit 
- Outline of common features 
4. What is the difference between Hemoglobin and Hematocrit 
- Comparison of major differences


Key terms

Anemia, hematocrit, hemoglobin, red blood cells, tissue oxygen

What is Hemoglobin

Hemoglobin (Hb) is an iron-rich protein that occurs in red blood cells. Therefore, the main function of hemoglobin is to carry oxygen throughout the body, supplying it to metabolic tissues. Thus, there must be sufficient hemoglobin levels in the blood for adequate tissue oxidation. The reference value of hemoglobin is 14 to 18 g / dL in men while 12 to 16 g / dL in women. However, low hemoglobin levels in the blood indicate anemic conditions. Conversely, high hemoglobin levels can be identified by erythrocytosis, which is the result of excessive amounts of red blood cells in the blood.

What is Hemoglobin
What is Hemoglobin


Figure 1: Hemoglobin structure

A well-mixed EDTA-anticoagulant whole blood sample is used to measure hemoglobin levels in the blood. First, all hemoglobin in the blood is converted to cyanometer hemoglobin, which is then measured by a colorimeter. In addition, hemoglobin electrophoresis is another method that measures the mobility of hemoglobin in an electric field.


What is Hematocrit

Hematocrit (HCT) (HT) is the measurement of the number of red blood cells in relation to the total volume of blood. Several methods are responsible for measuring hematocrit. The two main methods are a direct measurement of hematocrit by microhematocrit centrifugation and indirectly the calculation of hematocrit. In addition, the automated cell counter can be calculated by multiplying the red cell count (millions / mm) 3 ) by the median volume (MCV). Here, MCV is the average volume of a red blood cell.


What is Hematocrit


Figure 2: hematocrit

However, measurement of hematocrit, as well as hemoglobin levels, depends on plasma volume. Both values ​​appear to be higher in severely dehydrated individuals, whereas they are reduced in individuals with fluid overload. In both cases, to assume normal values, independent radionuclides of red cells and plasma have to be evaluated.


Similarities between hemoglobin and hematocrit


  • Hemoglobin and hematocrit are two measurements of the oxygen-carrying capacity of red blood cells.
  • Whole blood is taken to measure both hemoglobin levels and hematocrit. Therefore, both measurements depend on the plasma volume.
  • In addition, hematocrit (%) is equal to three times the value of hemoglobin (g / dL).
  • In addition, abnormally low measurements of hemoglobin and hematocrit indicate anemic conditions.

Difference between hemoglobin and hematocrit

Definition

Hemoglobin refers to a red protein responsible for the transport of oxygen into the blood of vertebrates, while hematocrit refers to the ratio of the number of red blood cells to the total volume of blood. This is the main difference between hemoglobin and hematocrit.


The Measurement

In addition, the hemoglobin test measures the amount of hemoglobin per unit volume of blood while the hematocrit measures the number of red blood cells in relation to the total blood volume.


Reference Value

Hemoglobin levels for men are 14 to 18 g / dL; 12 to 16 g / dL for women while normal hematocrit should be 40 to 54% for men; For women, it should be 36 to 48%. This is another difference between hemoglobin and hematocrit.


Anemia

In addition, low hemoglobin levels indicate anemia while hematocrit is an accelerated method of diagnosing anemia.


The Conclusion

Hemoglobin is an iron-rich protein found in red blood cells. Hemoglobin levels indicate the amount of hemoglobin present per unit volume of a person's blood. In comparison, hematocrit is the number of red blood cells in relation to blood volume. Therefore, both hemoglobin levels and hematocrit measure the ability of blood to carry oxygen. However, the main difference between hemoglobin and hematocrit is the type of parameters measured.


References:

1. Billett HH. Hemoglobin and hematocrit. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: History, Physical and Laboratory Examination. third edition. Boston: Butterworth; 1990. Chapter 151.

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What is the Difference Between Hemoglobin and Hematocrit, Normal Hematocrit
The main difference between hemoglobin and hematocrit is that hemoglobin is an iron-containing protein responsible for carrying oxygen to red blood cells, whereas hematocrit is the amount of red blood cells compared to total blood volume.
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